Accelerating Topical Anaesthesia Using Microneedles

Topical anaesthesia for children's lacerations.

Objective-To compare the anaesthetic properties of conventional intradermal 1% plain lignocaine with a topical gel preparation of adrenaline (1:2000) and cocaine (4-7%) for use in treatment of children's lacerations. Methods-Children aged 3-16 years with lacerations (not of the digits or mucous membranes) were consecutively assigned to receive either adrenaline and cocaine (AC) or lignocaine. P...

Fabrication of conical microneedles array using photolithography

Background and Aim: Microneedle technology has led to huge changes in the field of drug delivery medicine. Using microneedles, the drug can be injected locally, painlessly, and in very low and controlled doses with high precision. Local drug delivery through the skin with microneedles has many advantages over other methods of drug delivery. In this method, the drug does not enter the gastrointe...

Ocular Drug Delivery Using Microneedles

To my dearest parents For their love, trust and supports ACKNOWLEGMENT I would like to thank my advisor, my thesis committee members, my research colleagues, my family and my friends who made this thesis possible. I would like to thank my thesis advisor, Mark Prausnitz for his support during my thesis work. Without his guidance, it would be difficult for me to complete my study. I would like to...

Topical anaesthesia in upper gastrointestinal endoscopy.

Topical anaesthesia for repair of minor lacerations.

One hundred traumatic skin wounds were sutured under topical anaesthesia using a solution of lignocaine, adrenaline, and cocaine, and the effectiveness of the anaesthesia produced was assessed on a behavioural scale. The procedure was tolerated well by 63 patients, poorly by 11, and in 26 the response was uncertain. The response correlated well with age and with the field of anaesthesia measure...